Structure of the catalytic and UBA domains of the kinase MARK1
نویسندگان
چکیده
Members of the MARK subfamily of the CaMK protein kinases phosphorylate microtubuleassociated proteins tau, MAP2, and MAP4 which are involved in the regulation of the cytoskeleton and the microtubule-based transport by motor proteins of the kinesin family [1]. Hyperphosphorylation of neuronal tau by MARK is a potential cause for the aggregation of tau and the formation of paired helical filaments which are a hallmark of Alzheimer's disease. Homologues of MARK in Drosophila and C. elegans (Par-1) and in fission yeast (KIN1) are essential for the development of cell polarity.
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Effects of T208E activating mutation on MARK2 protein structure and dynamics: Modeling and simulation
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